TY - JOUR T1 - ANTIPYRETIC AND TOXIC EFFECTS OF COMBINATIONS OF ACETANILID WITH SODIUM BROMIDE AND WITH CAFFEINE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 200 LP - 205 VL - 55 IS - 2 AU - PAUL K. SMITH AU - W. E. HAMBOURGER Y1 - 1935/10/01 UR - http://jpet.aspetjournals.org/content/55/2/200.abstract N2 - The "lethal dose" (i.e., the dose causing death to 50 per cent of treated animals), of sodium bromide in adult albino rats is approximately 3500 mgm. per kilogram of body weight. The "lethal dose" of caffeine is approximately 200 mgm. per kilogram. Combinations of acetanilid and sodium bromide cause fewer fatalities than if their toxic actions were purely additive. Combinations of acetanilid and caffeine are almost exactly additive in their toxic effects as judged by the "lethal dose." A combination of acetanilid, sodium bromide, and caffeine given in two different sized doses was much less toxic than predicted on the assumption that their effects were additive. Sodium bromide slightly antagonizes the antipyretic action of acetanilid. Caffeine raises the temperature of fevered rats and antagonizes the antipyretic action of acetanilid. Sodium bromide and caffeine together antagonize to a large extent the antipyretic action of acetanilid. ER -