PT  - JOURNAL ARTICLE
AU  - AXEL M. HJORT
AU  - EDWIN J. DEBEER
AU  - JOHANNES S. BUCK
AU  - WALTER S. IDE
TI  - SOME UNSYMMETRICAL ALKYLARYL UREAS PREPARATION, PHYSICAL PROPERTIES AND HYPNOTIC EFFECTS
DP  - 1935 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 152--172
VI  - 55
IP  - 2
4099  - http://jpet.aspetjournals.org/content/55/2/152.short
4100  - http://jpet.aspetjournals.org/content/55/2/152.full
SO  - J Pharmacol Exp Ther1935 Oct 01; 55
AB  - 1. Twenty-nine unsymmetrical alkylaryl ureas, the majority of them new, were synthesized and their hypnotic potencies and toxicities determined by intraperitoneal injection in albino mice. 2. A series of 13 commonly used commercial hypnotics were tested in a like manner for purposes of comparison. 3. When these ureas are compared in homologous series their hypnotic potencies are seen to increase approximately two-fold for each addition of a CH2 group in their aliphatic portion. 4. There appears to be no consistent relationship between water solubility and hypnotic potency and toxicity. 5. In general, the Heptane/Water distribution coefficients parallel hypnotic potency and toxicity. 6. The more potent unsymmetrical alkylaryl ureas are more effective in lowering surface tension.