RT Journal Article
SR Electronic
T1 THE RESPIRATORY EFFECTS OF MORPHINE, CODEINE AND RELATED SUBSTANCES IV. THE EFFECT OF α-MONOACETYLMORPHINE, MONOACETYLDIHYDROMORPHINE, DIACETYLMORPHINE (HEROIN) AND DIACETYLDIHYDROMORPHINE ON THE RESPIRATORY ACTIVITY OF THE RABBIT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 25
OP 33
VO 54
IS 1
A1 CHARLES I. WRIGHT
A1 FLEMING A. BARBOUR
YR 1935
UL http://jpet.aspetjournals.org/content/54/1/25.abstract
AB α-Monoacetylmorphine, diacetylmorphine and two hydrogenated acetyl derivatives have been compared as to their effectiveness in decreasing the rabbits' respiratory rate, minute volume and sensitivity to stimulation by carbon dioxide. Observations were also made of the effect of the drugs on rectal temperature and heart rate. The least doses (milligram per kilogram) causing a decrease in respiratory activity are (a) α-monoacetylmorphine, 0.03, (b) monoacetyldihydromorphine, 0.2 to 0.25, (c) diacetylmorphine, 0.02 to 0.04, (d) diacetyldihydromorphine, 0.2 to 0.25.