RT Journal Article
SR Electronic
T1 FFFECT OF MORPHINE ON THE OXYGEN CONSUMPTION OF BRAIN TISSUE IN THE RAT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 156
OP 168
VO 53
IS 2
A1 E. G. GROSS
A1 I. H. PIERCE
YR 1935
UL http://jpet.aspetjournals.org/content/53/2/156.abstract
AB 1. Morphine added to hashed brain tissue of the rat decreases the oxygen consumption due to added glucose. 2. Brain from non-tolerant animals killed one hour after a subcutaneous injection of morphine show an increased oxygen consumption over the normal for a period of four to five hours, due to the increased glucose. 3. Brain from morphine-tolerant rats exhibits the same metabolic rate as that from normal animals. 4. Subcutaneous injection of morphine into non-tolerant animals produces no change in the metabolic rate of kidney and testis.