TY - JOUR T1 - THE TENSION OUTPUT OF CAFFEINIZED MUSCLES JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 142 LP - 155 VL - 53 IS - 2 AU - G. SASLOW AU - E. C. WEBSTER Y1 - 1935/02/01 UR - http://jpet.aspetjournals.org/content/53/2/142.abstract N2 - The action of caffeine on muscle at concentrations below contracture level has been investigated with a rigidly controlled method involving the measurement of the total work of the muscle on a tension lever. Opposite actions of the drug, beneficial at low concentrations and injurious at high, were not observed. The drug, in concentrations at which it was effective, invariably reduced the tension output of the frog gastrocnemius. The depressant effect could be abolished completely by washing with Ringer, provided that the caffeine concentration employed was 0.05 per cent or lower. ER -