RT Journal Article
SR Electronic
T1 THE TENSION OUTPUT OF CAFFEINIZED MUSCLES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 142
OP 155
VO 53
IS 2
A1 G. SASLOW
A1 E. C. WEBSTER
YR 1935
UL http://jpet.aspetjournals.org/content/53/2/142.abstract
AB The action of caffeine on muscle at concentrations below contracture level has been investigated with a rigidly controlled method involving the measurement of the total work of the muscle on a tension lever. Opposite actions of the drug, beneficial at low concentrations and injurious at high, were not observed. The drug, in concentrations at which it was effective, invariably reduced the tension output of the frog gastrocnemius. The depressant effect could be abolished completely by washing with Ringer, provided that the caffeine concentration employed was 0.05 per cent or lower.