TY - JOUR T1 - STUDIES ON BARBITURATES VII. EXPERIMENTAL ANALYSIS OF BARBITAL ACTION JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 91 LP - 100 VL - 52 IS - 1 AU - THEODORE KOPPANYI AU - JAMES M. DILLE Y1 - 1934/09/01 UR - http://jpet.aspetjournals.org/content/52/1/91.abstract N2 - Rabbits receiving daily doses of barbital show a lag in excretion. After the administration of 50 or 100 mgm. per kilogram, there is no accumulation of effects. Albino rabbits are more susceptible to toxic effects of barbital. Cats although showing an optimum excretion of barbital, exhibit accumulation of effects terminating in depression, coma, and respiratory failure. An analysis of these results indicates that rabbits acquire the ability to oxidize barbital, whereas in cats and dogs the depression after maximum excretion of barbital is due to retention of the drug by the brain cells. ER -