TY - JOUR T1 - THE EFFECT OF TISSUE EXTRACT AND OTHER VASCULAR DEPRESSOR SUBSTANCES ON ISOLATED INTESTINES JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 421 LP - 429 VL - 51 IS - 4 AU - JEAN D. CRAVEN AU - FOREST D. McCREA Y1 - 1934/08/01 UR - http://jpet.aspetjournals.org/content/51/4/421.abstract N2 - 1. Tissue extract produced a contraction of all segments of the intestine of guinea pigs, but did not contract the intestine of rats or rabbits. 2. Tissue extract caused contraction only in alkaline solutions, relaxation occurring when the reaction of the solutions was slightly acid. 3. The action of tissue extract on the guinea pig, rat, and rabbit intestines was similar to that of histamine. 4. The active principle of tissue extract is not acetylcholine or methylguanidine. 5. Permutit absorbed the active principle of tissue extract as well as that of histamine. ER -