RT Journal Article
SR Electronic
T1 THE RESPIRATORY EFFECTS OF MORPHINE, CODEINE AND RELATED SUBSTANCES I. THE EFFECT OF CODEINE, ISOCODEINE, ALLOPSEUDOCODEINE AND PSEUDOCODEINE ON THE RESPIRATION OF THE RABBIT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 327
OP 342
VO 51
IS 3
A1 CHARLES I. WRIGHT
YR 1934
UL http://jpet.aspetjournals.org/content/51/3/327.abstract
AB Codeine, isocodeine, pseudocodeine and allopseudocodeine have been compared as to their effectiveness in decreasing the rabbit's respiratory rate, minute volume and sensitivity to stimulation by carbon dioxide. The drugs were injected subcutaneously. The minimum doses (milligrams per kilogram of the base) required to decrease respiration are (a) codeine 1.6 to 2.4; (b) isocodeine 2.6 to 3.9; (c) pseudocodeine 76 to 98. Allopseudocodeine hydrochloride does not decrease respiratory activity at less than the convulsant dose. At doses above 10 mgm. per kilogram isocodeine is more effective than codeine in depressing respiration due to the convulsant action of the latter.