PT - JOURNAL ARTICLE AU - V. E. HENDERSON AU - M. H. ROEPKE TI - THE RÔLE OF ACETYLCHOLINE IN BLADDER CONTRACTILE MECHANISMS AND IN PARASYMPATHETIC GANGLIA DP - 1934 May 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 97--111 VI - 51 IP - 1 4099 - http://jpet.aspetjournals.org/content/51/1/97.short 4100 - http://jpet.aspetjournals.org/content/51/1/97.full SO - J Pharmacol Exp Ther1934 May 01; 51 AB - 1. We believe that our experiments have shown that (a) there is both a contractile and tonus mechanism in the bladder; (b) that the stimulation of tonus nerve fibres is mediated by the production of acetylcholine in the bladder and (c) that the stimulation of the contractile nerve fibres is not mediated by acetylcholine but in some other way. 2. Atropine depresses the tonus mechanism, but not the contractile one. 3. Our experiments suggest that acetylcholine is the mediating substance between pre- and postganglionic fibres in parasympathetic nerve ganglia, as has been shown with sympathetic ganglia. 4. Atropine does not affect the action of the mediating acetylcholine in autonomic ganglia.