PT  - JOURNAL ARTICLE
AU  - HUGO KRUEGER
TI  - THE EFFECTS OF MORPHINE AND ITS DERIVATIVES ON INTESTINAL MOVEMENTS 2. THE EFFECT OF MORPHINE ON THE PRESSURES DEVELOPED BY THE INTESTINAL MUSCULATURE
DP  - 1934 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 85--96
VI  - 51
IP  - 1
4099  - http://jpet.aspetjournals.org/content/51/1/85.short
4100  - http://jpet.aspetjournals.org/content/51/1/85.full
SO  - J Pharmacol Exp Ther1934 May 01; 51
AB  - The injection of morphine subcutaneously is followed by an increase in magnitude of movement, of pressures developed, and of the work done by the intestinal muscle of an ileal loop in the dog. These results lead to the further tentative conclusion that morphine increases the oxygen consumption of smooth muscle. The high pressures developed after morphine may be a factor in the constipating effect of this drug. It is suggested that clinicians should determine whether such high pressures in the intestinal lumen develop in the case of man after the use of morphine and whether or not these pressures, if occurring, would be deleterious for cases involving weakened or distended portions of the gastro-intestinal tract.