TY - JOUR T1 - THE ACTION OF SODIUM OXALATE IN NORMAL AND THYROPARATHYROIDECTOMIZED CATS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 117 LP - 132 VL - 49 IS - 1 AU - WILLIAM SALANT AU - WILLIAM M. PARKINS Y1 - 1933/09/01 UR - http://jpet.aspetjournals.org/content/49/1/117.abstract N2 - 1. Small and medium amounts of oxalate injected intravenously into normal cats usually produced a marked increase of the intestinal movements when the vagi were intact, but stimulation was moderate or nil when the same amounts were given to cats after double vagotomy. 2. Oxalate was without effect on the intestine when the vagi were intact if it was injected after effective doses of atropine. 3. Large doses of oxalate produced inhibition in cats with vagi intact as well as after double vagotomy. 4. Oxalate given after ergotamine usually caused powerful stimulation of the intestinal contractions. This occurred even when oxalate before ergotamine produced marked inhibition. 5. The relation of the two substances was discussed and the conclusion was reached that stimulation by oxalate after ergotamine was due to action on the endings of the parasympathetic reënforced by diminished irritability of the endings of the sympathetic fibers produced by ergotamine. 6. Small and medium amounts of oxalate caused a fall or a slight rise of blood pressure in cats with vagi intact, but pressor action predominated when the same amounts were given after division of both vagi and especially when the vagal endings were paralyzed by atropine, the effect being pronounced in some cases. 7. Large amounts of oxalate generally produced depression of the circulation. The effect of oxalate, whatever the amount, was cardiac in origin. 8. The effects produced on the circulation and on the intestine when the vagi were intact and after double vagotomy indicate stimulation of the vagus center by oxalate. 9. Its action after atropine also signifies stimulation of the parasympathetic endings in the heart and in the intestine. 10. The rise of blood pressure produced by oxalate after atropine being cardiac in origin, the effect was attributed to direct stimulation of the heart muscle. 11. Respiration was stimulated by medium and depressed by large amounts of oxalate. 12. In thyroparathyroidectomized cats the effect of oxalate on the intestinal movements was irregular, but in several instances stimulation was observed after the total amounts injected were far in excess of those which produced inhibition in normal cats. 13. Its action on the circulation was characterized by a tendency to produce stimulation. Absence of depression was observed even when very large amounts had been injected. Stimulation by oxalate was more frequently observed and was greater in thyroparathyroidectomized than in normal cats. 14. The resistance of thyroparathyroidectomized cats to oxalate was much greater than in normal cats. 15. The relation of calcium to the action of oxalate was discussed, and the conclusion was reached that other factors besides calcium might be concerned in the effects of oxalate. ER -