PT  - JOURNAL ARTICLE
AU  - FREDERICK BERNHEIM
TI  - ACTION OF DRUGS ON THE ISOLATED INTESTINE OF CERTAIN TELEOST FISH
DP  - 1934 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 216--222
VI  - 50
IP  - 2
4099  - http://jpet.aspetjournals.org/content/50/2/216.short
4100  - http://jpet.aspetjournals.org/content/50/2/216.full
SO  - J Pharmacol Exp Ther1934 Feb 01; 50
AB  - 1. Acetylcholine, pilocarpine and barium cause sustained contractions of the isolated intestine and stomach of teleost fish whereas histamin and physostigmine are practically without action. 2. Atropin causes immediate relaxation of the intestine contracted by acetylcholine or pilocarpine, but epinephrine causes further contraction which is only rarely followed by relaxation. 3. Epinephrine will cause relaxation in an intestine contracted by mechanical stimuli. 4. Nicotine added after acetylcholine or pilocarpine causes further contraction which is sustained. Even in concentrations of one part in five hundred, it fails to produce relaxation. 5. The calcium ion is necessary for contraction.