TY - JOUR T1 - THE INHIBITION OF OESTRUS BY EXTRACTS OF THE ANTERIOR LOBE OF THE PITUITARY BODY JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 269 LP - 280 VL - 47 IS - 3 AU - MARIE C. D'AMOUR AU - H. B. VAN DYKE Y1 - 1933/03/01 UR - http://jpet.aspetjournals.org/content/47/3/269.abstract N2 - 1. Extracts capable of causing the inhibition of oestrus in the adult female white rat were prepared from both beef anterior lobes and from sheep whole pituitary bodies. It was found best to carry out extraction at an alkaline pH. Glands which had been desiccated by acetone and subsequently powdered were found to be satisfactory. 2. Extracts of sheep whole pituitary body (compared with those of beef anterior lobe) were consistently found to be more potent both in stimulating the ovary of the immature rat and in inhibiting oestrus in the adult rat. 3. Extracts of nine control tissues caused no lengthening of the oestrous cycle. The characteristic ovarian changes found in the animals receiving anterior pituitary extracts were not observed in the ovaries of animals receiving extracts of other tissues. 4. The assay of extracts causing the inhibition of oestrus is discussed. ER -