RT Journal Article
SR Electronic
T1 THE ACTION OF COCAINE ON THE INTESTINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 209
OP 214
VO 49
IS 2
A1 FREDERICK BERNHEIM
YR 1933
UL http://jpet.aspetjournals.org/content/49/2/209.abstract
AB 1. Cocaine in concentrations of 0.1 to 0.2 per cent causes relaxation of the guinea pig ileum contracted by histamin or pilocarpine. The extent of the relaxation is a function of the amount of cocaine added and the amount of histamin or pilocarpine. 2. Cocaine causes relaxation of the ileum after contraction by barium. 3. The action of nicotine and cocaine is additive. 4. It is concluded that cocaine like nicotine and atropine acts both on smooth muscle directly and on the parasympathetic endings.