TY - JOUR T1 - THE TOLERANCE OF THE TOAD TOWARDS STROPHANTHIN JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 697 LP - 708 VL - 43 IS - 4 AU - DAVID EPSTEIN Y1 - 1931/12/01 UR - http://jpet.aspetjournals.org/content/43/4/697.abstract N2 - 1. The toad Bufo regularis is about 1000 times more tolerant to strophanthin than the frog Xenopus laevis. 2. The same degree of tolerance is shown by the perfused heart of the toad, so that the tolerance of the toad to strophanthin can be completely explained as due to the tolerance of its heart. 3. Strophanthin is able to produce systolic standstill of the heart of the toad, as in the case of the frog. 4. Strophanthin exerts a direct stimulant effect on the spinal cord of the toad resulting in strychnine-like convulsions. This may later be followed by complete paralysis of the nervous system. 5. A possible error that may occur when drugs are injected into the ventral lymph sacs has been referred to, and the use of alternative sites of injection has been suggested. ER -