TY - JOUR T1 - CHRONIC EXPERIMENTAL BARBITAL POISONING JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 217 LP - 231 VL - 42 IS - 2 AU - M. H. SEEVERS AU - A. L. TATUM Y1 - 1931/06/01 UR - http://jpet.aspetjournals.org/content/42/2/217.abstract N2 - 1. Chronic barbital poisoning in dogs reveals: (a) A slight grade of tolerance existing for a time; (b) following the more tolerant period, a static stage, which in turn is followed by a stage of intolerance. 2. Damage to the central nervous system occurs, which can be related to progress and symptomatology of the chronic poisoning. 3. Experimental evidences herein presented furnish a basis for a more thorough understanding of the problems involved in chronic poisoning and addiction to barbiturates in man. ER -