RT Journal Article
SR Electronic
T1 FURTHER STUDIES OF THE CONTROL OF EXPERIMENTALLY PRODUCED CONVULSIONS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 449
OP 455
VO 44
IS 4
A1 HADDOW M. KEITH
YR 1932
UL http://jpet.aspetjournals.org/content/44/4/449.abstract
AB In rabbits the anticonvulsive effect of diacetone alcohol given by mouth is definite. A considerably larger amount of it is required than is required of phenobarbital to produce a similar effect. The latter, however, is much more toxic in larger doses, and causes considerably more irritability to sensory stimuli. The anticonvulsive properties of diacetone alcohol depend on the acetone portion of the molecule. β-hydroxybutyric acid, in itself, is not anticonvulsive.