RT Journal Article
SR Electronic
T1 THE TESTING OF LOCAL ANESTHETICS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 329
OP 341
VO 39
IS 3
A1 T. H. RIDER
YR 1930
UL http://jpet.aspetjournals.org/content/39/3/329.abstract
AB 1. A new method of testing the local anesthetic activities of drugs on the sciatic nerve of the frog has been described. This method is more rapid, simpler and more reproducible than previous ones. 2. The effects of seasonal variations of frogs on anesthesia time is discussed, and some suggestive results are given for the anethesia of the sciatic nerves of laboratory-starved winter frogs. 3. Modifications are suggested for the determination of anesthesia times on the rabbit's cornea and the accuracy of results is discussed. 4. A long-lasting increase in the resistance of the rabbit's cornea to anesthetization by cocaine solutions after their frequent instillation has been described. 5. The advantages of the acceptance of a standard and reproducible technique of testing local anesthetics has been stressed.