RT Journal Article
SR Electronic
T1 FURTHER OBSERVATIONS ON THE EFFECT OF PITUITARY EXTRACT AND MORPHINE SULPHATE UPON EXCISED DOG'S INTESTINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 401
OP 410
VO 38
IS 4
A1 CHARLES M. GRUBER
A1 GARRETT PIPKIN
YR 1930
UL http://jpet.aspetjournals.org/content/38/4/401.abstract
AB 1. High dilutions of pituitary extract if effective cause an increase in tonus and tonus oscillations in longitudinal segments of excised dogs intestine. 2. High concentrations of pituitary extract cause an immediate loss in general tonus and complete disappearance of the rhythmic contractions. 3. The degree of tonus normally present in the segment before the addition of pituitary extract is a factor in the results obtained. If the tonus is high, even dilute solutions may cause relaxation while if the tonus is low the strong solution may stimulate the gut. 4. Morphine sulphate increases the tonus, and, in many instances the height of rhythmic contractions, in excised segments of normal dog intestine. A similar action is noted in excised longitudinal segments taken from a Thiry-Vella loop. 5. Papaverine antagonizes the morphine action in both types of segments.