TY - JOUR T1 - SOME EFFECTS OF ALCOHOL UPON THE NORMAL AND DAMAGED LIVER JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 291 LP - 301 VL - 38 IS - 3 AU - SANDFORD M. ROSENTHAL Y1 - 1930/03/01 UR - http://jpet.aspetjournals.org/content/38/3/291.abstract N2 - Alcohol orally administered to normal dogs in doses of 2 cc. per kilogram produces no increase of urobilin in the urine or bilirubin in the blood. There is a slight impairment indicated by the bromsulphthalein test, which returns to normal in twenty-four hours. Alcohol produces no greater disturbance of function in dogs whose livers have been damaged by chloroform or carbon tetrachloride than it does in normal dogs. In spite of the negligible disturbance as shown by tests of liver function, alcohol greatly increases the susceptibility of dogs to chloroform (by inhalation) even after the visible effects of alcohol have worn off. A two-hour period of anesthesia was fatal to 6 of 10 dogs who had received 2 cc. of alcohol per kilogram (by mouth) three to four hours prior to the anesthetic. As a control 10 dogs received a similar period of chloroform anesthesia alone, without a fatality. ER -