PT  - JOURNAL ARTICLE
AU  - SAMSON WRIGHT
AU  - J. H. THOMPSON
TI  - EFFECTS OF PURE NITROUS OXIDE ANESTHESIA ON HUMAN BLOOD PRESSURE
DP  - 1930 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 247--259
VI  - 38
IP  - 3
4099  - http://jpet.aspetjournals.org/content/38/3/247.short
4100  - http://jpet.aspetjournals.org/content/38/3/247.full
SO  - J Pharmacol Exp Ther1930 Mar 01; 38
AB  - 1. The blood pressure changes in man have been studied during pure nitrous oxide anesthesia. 2. The usual result is a slight initial rise which is clearly emotional in origin, followed by a secondary decline, which may pass into a fall or an after-fall. There may, however, be no change at all, or a fall from the beginning, or an after-rise. 3. The circulatory effects of pure nitrous oxide are probably entirely due to the accompanying anoxemia. 4. The total blood pressure response to nitrous oxide inhalation in man probably depends on the way in which a number of factors interact: (a) emotional stimulation of the vasomotor center; (b) reactiveness of the vasomotor center to acute anoxemia; (c) extent of adrenaline secretion; (d) the time of onset and extent of the weakening of the myocardium. Coincident respiratory changes are of minor significance.