RT Journal Article
SR Electronic
T1 THE LIBERATION OF FORMALDEHYDE IN THE AQUEOUS HUMOUR OF THE EYE AFTER ADMINISTRATION OF HEXAMINE (UROTROPINE)
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 231
OP 239
VO 38
IS 2
A1 M. A.F. SHERIF
YR 1930
UL http://jpet.aspetjournals.org/content/38/2/231.abstract
AB 1. It is shown (a) the pH of the aqueous humour of a rabbit rises very rapidly when exposed to the air, (b) the pH of this fluid can be reduced by intravenous injections of acid sodium phosphate, (c) under suitable conditions, urotropine liberates formaldehyde in aqueous humour and cerebrospinal fluid of rabbits. 2. Keeping the dose of acid phosphate constant and varying the dosage of urotropine, a dose of 0.05 gram per kilogram still liberates formaldehyde in aqueous humour and in cerebrospinal fluid. 3. Varying the dosage of acid phosphate and keeping the urotropine dosage constant, no formaldehyde is formed when the intravenous dose of acid phosphate is below 0.25 gram per kilogram. 4. The possibility of formaldehyde being liberated in inflamed tissues after urotropine administration is discussed.