PT - JOURNAL ARTICLE AU - H. H. DIXON AU - S. W. RANSON TI - THE EFFECT OF AMMONIUM CHLORIDE ON THE DEVELOPMENT OF RIGIDITY IN EXPERIMENTAL LOCAL TETANUS DP - 1930 Jan 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 51--55 VI - 38 IP - 1 4099 - http://jpet.aspetjournals.org/content/38/1/51.short 4100 - http://jpet.aspetjournals.org/content/38/1/51.full SO - J Pharmacol Exp Ther1930 Jan 01; 38 AB - Large doses of ammonium chloride relieve the rigidity of the extensor muscles caused by tetanus toxin in white rats and prevent the development of contracture or general tetanus if the dose of toxin has been a moderate one. Whether this beneficial effect is due to acidosis or to a specific action of the ammonium radical was not determined but other substances that cause acidosis were without effect as was also ammonium acetate. The progress of the experimental tetanus was not affected by such alterations of the serum calcium as could be produced by the administration of fairly large doses of sodium fluoride, neutral sodium phosphate, or calcium chloride.