TY - JOUR T1 - ON THE PREGNANCY-RESPONSE OF THE UTERUS OF THE CAT JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 379 LP - 397 VL - 37 IS - 4 AU - H. B. VAN DYKE AU - R. G. GUSTAVSON Y1 - 1929/12/01 UR - http://jpet.aspetjournals.org/content/37/4/379.abstract N2 - If the hypogastric nerves of the cat are stimulated, it is well known that the non-pregnant uterus relaxes, while the pregnant uterus contracts. The attempt has been made to cause this pregnancy-response in ovariectomized and non-ovariectomized virgin or non-pregnant cats by the subcutaneous administration of various extracts. The following results were obtained: 1. Ovariectomy did not alter the response of the non-pregnant cat's uterus. 2. Ovariectomy in the pregnant cat, accompanied in our experiments by fetal resorption, was without effect unless fetal resorption was complete. In the latter case the uterus behaved like a non-pregnant uterus. 3. A foreign body introduced into the non-pregnant uterus had no effect on the response. 4. Placental and follicular-liquid extracts provoked marked uterine hypertrophy without any pregnancy-reversal of the uterus. 5. Extracts of early vascularized and late vascularized corpora lutea, ovarian residue, uterus and fetus caused little or no uterine hypertrophy and no alteration of response. 6. Lipoidal extracts of mature corpora lutea caused pronounced uterine hypertrophy in experiments with three kittens. A contraction of the uterus simulating pregnancy repeatedly occurred in two of these experiments when the hypogastric nerves were stimulated. Aqueous extracts of mature corpora lutea administered with placental hormone also caused this reversal simulating pregnancy in two of three animals. This effect seemed specific for corpus-luteum extract and probably was due to a substance other than that provoking estrus. ER -