PT - JOURNAL ARTICLE AU - HAMILTON H. ANDERSON AU - MEI-YO CHEN AU - CHAUNCEY D. LEAKE TI - THE EFFECTS OF BARBITURIC ACID HYPNOTICS ON BASAL METABOLISM IN HUMANS DP - 1930 Oct 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 215--228 VI - 40 IP - 2 4099 - http://jpet.aspetjournals.org/content/40/2/215.short 4100 - http://jpet.aspetjournals.org/content/40/2/215.full SO - J Pharmacol Exp Ther1930 Oct 01; 40 AB - Within the recommended therapeutic doses by mouth in human subjects, barbital, ipral, neonal, and phanodorn tend to reduce oxygen consumption and tactile discrimination, but to increase respiratory rate. Dial seems to have little constant effect on oxygen consumption, although it depresses tactile discrimination. Amytal and phenobarbital tend to increase oxygen consumption except in relatively high dosage. Barbital seems more uniformly depressing than its common derivatives, not only on basal rate and attention, but also on pulse rate and blood pressure. If no significant analgesic effect is desired, barbital by mouth may be recommended as a substitute for morphine in preanesthetic medication. The dosage should depend on the particular needs of the individual patient. Commercially available barbital derivatives seem to offer no advantages over barbital in this respect, but may exhibit more frequent untoward reactions, and are usually much more expensive.