TY - JOUR T1 - THE EFFECT OF INTRAVENOUS INJECTIONS OF COLLOIDAL LEAD UPON THE CIRCULATORY SYSTEM JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 449 LP - 462 VL - 35 IS - 4 AU - WALTER J. DILLING Y1 - 1929/04/01 UR - http://jpet.aspetjournals.org/content/35/4/449.abstract N2 - 1. Lead salts or colloidal lead preparations containing free lead ion impair the contractility of the auricle and ventricle in the frog's heart and may cause heart block. A true colloidal suspension does not influence the heart. 2. In mammals, injections of ionized lead solutions and certain colloidal lead preparations produce brief but serious weakening of the auricular movements with consequent diminution of the force of the pulse and fall of blood pressure. Compensatory acceleration of the cardiac rhythm is frequently observed. 3. Satisfactory preparations of colloidal lead produce negligible effects on the circulatory system unless idiosyncrasy is encountered. 4. Colloidal lead preparations, before being used upon patients, should be tested to ensure (a) that they are free from toxic effects upon rabbits and (b) that they cause only a negligible fall in blood pressure. 5. Myocardial disease is a contraindication to the use of colloidal lead in the treatment of malignant disease. ER -