PT - JOURNAL ARTICLE AU - WM. DEB. MACNIDER TI - A STUDY OF THE ACTION OF VARIOUS DIURETICS IN URANIUM NEPHRITIS DP - 1912 Mar 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 423--439 VI - 3 IP - 4 4099 - http://jpet.aspetjournals.org/content/3/4/423.short 4100 - http://jpet.aspetjournals.org/content/3/4/423.full SO - J Pharmacol Exp Ther1912 Mar 01; 3 AB - 1. Early in a uranium nephritis, usually within the first twenty-four hours, the animals develop a glycosuria and become markedly polyuric. 2. Following an anesthetic, morphine-ether, or Gréhant's, these animals either become completely anuric or the output of urine is greatly reduced. 3. Such animals under the effect of caffeine, theobromine, digitalin and 0.9 per cent salt solution, show a normal response in the general blood pressure rise and in the vascular response of the kidney. 4. In certain of these animals the flow of urine is increased by these diuretics while in other animals the urine flow is uninfluenced. 5. Histologically the vascular pathology of the kidney is similar in those animals which show a diuretic effect and in those animals which remain anuric. 6. Those animals which remain anuric show a physiological vascular response on the part of the kidney vessels similar to the response which is obtained in the diuretic animals. The physiological and the pathological reaction of the kidney vessels in the anuric and in the diuretic animals are, therefore, similar. 7. The two groups of animals differ, however, in the degree of involvement of the epithelial element of the kidney. The anuric animals show an epithelial involvement which is severe and which results anatomically in an encroachment upon, or occlusion of, the lumen of the tubules, while in the diuretic animals the epithelial changes are less marked and are insufficient to produce a mechanical obstruction of the tubular lumen. 8. The pathology of the kidney of those animals with an early uranium nephritis which were examined prior to the use of an anesthetic showed a vascular pathology which in general was similar to the vascular pathology of the anuric, practically anuric and diuretic animals. The tubular epithelium of these animals, which were polyuric, showed but slight changes, and in their epithelial reaction the kidneys of these animals were more nearly comparable to the kidneys of the diuretic animals than they were to the kidneys of the anuric animals. The physiological and anatomical observations which have been made in this investigation indicate that in a uranium nephritis the epithelial changes are more responsible for a reduction in the output of urine or an anuria than are the vascular changes. The way in which these changes influence the output of urine will furnish the basis for a subsequent investigation.