TY - JOUR T1 - THE SEAT OF THE EMETIC ACTION OF THE DIGITALIS BODIES JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 295 LP - 300 VL - 33 IS - 3 AU - NATHAN B. EDDY AU - ROBERT A. HATCHER Y1 - 1928/07/01 UR - http://jpet.aspetjournals.org/content/33/3/295.abstract N2 - 1. The present investigation, together with that of Hatcher and Weiss, shows that nicotine abolishes the emetic action of all pure digitalis principles which are in common use, and also that of many of the crude drugs of this group. 2. A severely toxic dose of nicotine may be administered to a cat every half hour during many hours, showing that the drug is eliminated rapidly, but the action of nicotine whereby it abolishes the emetic action of digitalis bodies persists for three hours or more. ER -