PT  - JOURNAL ARTICLE
AU  - Norifumi Shioda
AU  - Yui Yamamoto
AU  - Feng Han
AU  - Shigeki Moriguchi
AU  - Yoshimasa Yamaguchi
AU  - Masataka Hino
AU  - Kohji Fukunaga
TI  - A Novel Cognitive Enhancer, ZSET1446/ST101, Promotes Hippocampal Neurogenesis and Ameliorates Depressive Behavior in Olfactory Bulbectomized Mice
AID  - 10.1124/jpet.109.163535
DP  - 2010 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 43--50
VI  - 333
IP  - 1
4099  - http://jpet.aspetjournals.org/content/333/1/43.short
4100  - http://jpet.aspetjournals.org/content/333/1/43.full
SO  - J Pharmacol Exp Ther2010 Apr 01; 333
AB  - In the adult brain, neurogenesis persistently occurs in the subgranular zone of the hippocampal dentate gyrus (DG), and impaired neurogenesis is implicated in depressive behaviors and poor learning memory. Here, we investigated the effects of oral administration of spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101), a novel cognitive enhancer stimulating acetylcholine release, on adult neurogenesis in olfactory bulbectomized (OBX) mice. OBX mice showed significant decreases in the number of newborn cells in the DG by immunohistochemical analysis of 5-bromo-2-deoxyuridine incorporation. Impaired neurogenesis observed in OBX mice was significantly improved by chronic administration with ZSET1446. We confirmed that administration with mecamylamine, a nicotinic acetylcholine receptor antagonist, inhibits ZSET1446-enhanced neurogenesis in the DG. ZSET1446 administration also restored decreased phosphorylation of Akt and extracellular signal-regulated kinase in the DG of OBX mice. Consistent with restored neurogenesis, chronic but not single ZSET1446 administration promoted significant decreases in immobility in tail suspension tests and improved cognitive behaviors in OBX mice. Taken together, chronic ZSET1446 administration antagonized impaired neurogenesis seen in OBX mice, an effect closely associated with improvement of depressive behavior.