TY - JOUR T1 - Antitumorigenic Effects of Cannabinoids beyond Apoptosis JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 336 LP - 344 DO - 10.1124/jpet.109.157735 VL - 332 IS - 2 AU - Nadine Freimuth AU - Robert Ramer AU - Burkhard Hinz Y1 - 2010/02/01 UR - http://jpet.aspetjournals.org/content/332/2/336.abstract N2 - According to the World Health Organization, the cases of death caused by cancer will have been doubled until the year 2030. By 2010, cancer is expected to be the number one cause of death. Therefore, it is necessary to explore novel approaches for the treatment of cancer. Over past years, the antitumorigenic effects of cannabinoids have emerged as an exciting field in cancer research. Apart from their proapoptotic and antiproliferative action, recent research has shown that cannabinoids may likewise affect tumor cell angiogenesis, migration, invasion, adhesion, and metastasization. This review will summarize the data concerning the influence of cannabinoids on these locomotive processes beyond modulation of cancer cell apoptosis and proliferation. The findings discussed here provide a new perspective on the antitumorigenic potential of cannabinoids. Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics ER -