RT Journal Article
SR Electronic
T1 A COMPARISON OF THE PHARMACOLOGICAL ACTION OF DIACETONE ALCOHOL AND ACETONE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 175
OP 183
VO 33
IS 2
A1 D. C. WALTON
A1 E. F. KEHR
A1 A. S. LOEVENHART
YR 1928
UL http://jpet.aspetjournals.org/content/33/2/175.abstract
AB 1. The comparison of the toxicity and pharmacological action of diacetone alcohol and acetone is of industrial importance since both are in wide use as commercial solvents. Their study is of interest because they offer an opportunity to compare a substance with its simplest polymer. 2. Diacetone alcohol is somewhat more toxic than acetone. Its soporific action develops more rapidly and a more constant depressant effect is noted upon the respiration. 3. Both substances produce a fall in blood pressure which is probably due to decreased cardiac output and which is independent of the vagal center.