PT  - JOURNAL ARTICLE
AU  - D. C. WALTON
AU  - E. F. KEHR
AU  - A. S. LOEVENHART
TI  - A COMPARISON OF THE PHARMACOLOGICAL ACTION OF DIACETONE ALCOHOL AND ACETONE
DP  - 1928 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 175--183
VI  - 33
IP  - 2
4099  - http://jpet.aspetjournals.org/content/33/2/175.short
4100  - http://jpet.aspetjournals.org/content/33/2/175.full
SO  - J Pharmacol Exp Ther1928 Jun 01; 33
AB  - 1. The comparison of the toxicity and pharmacological action of diacetone alcohol and acetone is of industrial importance since both are in wide use as commercial solvents. Their study is of interest because they offer an opportunity to compare a substance with its simplest polymer. 2. Diacetone alcohol is somewhat more toxic than acetone. Its soporific action develops more rapidly and a more constant depressant effect is noted upon the respiration. 3. Both substances produce a fall in blood pressure which is probably due to decreased cardiac output and which is independent of the vagal center.