TY - JOUR T1 - Inhibition of Presynaptic Release-Facilitatory Kainate Autoreceptors by Extracellular Cyclic GMP JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 210 LP - 219 DO - 10.1124/jpet.109.154955 VL - 332 IS - 1 AU - Chiara Cervetto AU - Guido Maura AU - Manuela Marcoli Y1 - 2010/01/01 UR - http://jpet.aspetjournals.org/content/332/1/210.abstract N2 - We found that both α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate autoreceptors were present on the glutamate-releasing terminals of cerebellar parallel/climbing fibers and that they functioned as facilitatory autoreceptors. Extracellular cGMP inhibited the neurotransmitter release evoked by presynaptic kainate receptor activation; the inhibitory effect of extracellular cGMP was selective for the kainate autoreceptor-mediated response and did not affect the AMPA autoreceptor-mediated response. Endogenously synthesized cGMP might be the physiological source for the extracellular cGMP modulating the response to kainate autoreceptor activation.© 2010 by The American Society for Pharmacology and Experimental Therapeutics ER -