RT Journal Article SR Electronic T1 Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 948 OP 956 DO 10.1124/jpet.107.132647 VO 324 IS 3 A1 Lothar Lindemann A1 Claas Aiko Meyer A1 Karine Jeanneau A1 Amyaouch Bradaia A1 Laurence Ozmen A1 Horst Bluethmann A1 Bernhard Bettler A1 Joseph G. Wettstein A1 Edilio Borroni A1 Jean-Luc Moreau A1 Marius C. Hoener YR 2008 UL http://jpet.aspetjournals.org/content/324/3/948.abstract AB The recent identification of the trace amine-associated receptor (TAAR)1 provides an opportunity to dissociate the effects of trace amines on the dopamine transporter from receptor-mediated effects. To separate both effects on a physiological level, a Taar1 knockout mouse line was generated. Taar1 knockout mice display increased sensitivity to amphetamine as revealed by enhanced amphetamine-triggered increases in locomotor activity and augmented striatal release of dopamine compared with wild-type animals. Under baseline conditions, locomotion and extracellular striatal dopamine levels were similar between Taar1 knockout and wild-type mice. Electrophysiological recordings revealed an elevated spontaneous firing rate of dopaminergic neurons in the ventral tegmental area of Taar1 knock-out mice. The endogenous TAAR1 agonist p-tyramine specifically decreased the spike frequency of these neurons in wild-type but not in Taar1 knockout mice, consistent with the prominent expression of Taar1 in the ventral tegmental area. Taken together, the data reveal TAAR1 as regulator of dopaminergic neurotransmission. The American Society for Pharmacology and Experimental Therapeutics