PT  - JOURNAL ARTICLE
AU  - Man Jiang
AU  - Zheng Dong
TI  - Regulation and Pathological Role of p53 in Cisplatin Nephrotoxicity
AID  - 10.1124/jpet.108.139162
DP  - 2008 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 300--307
VI  - 327
IP  - 2
4099  - http://jpet.aspetjournals.org/content/327/2/300.short
4100  - http://jpet.aspetjournals.org/content/327/2/300.full
SO  - J Pharmacol Exp Ther2008 Nov 01; 327
AB  - Cisplatin is one of the most potent chemotherapy drugs widely used for cancer treatment. However, its use is limited by side effects in normal tissues, particularly the kidneys. Recent studies, using both in vitro and in vivo experimental models, have suggested a critical role for p53 in cisplatin nephrotoxicity. The signaling pathways upstream and downstream of p53 are being investigated and related to renal cell injury and death. Along with the mechanistic studies, renoprotective approaches targeting p53 have been suggested. Further research may integrate p53 signaling with other nephrotoxic signaling pathways, providing a comprehensive understanding of cisplatin nephrotoxicity and leading to the development of effective renoprotective strategies during cancer therapy. The American Society for Pharmacology and Experimental Therapeutics