TY - JOUR T1 - ON THE ANTISEPTIC AND BACTERICIDAL ACTION OF THE SODIUM SALTS OF IODBENZOIC, IODOSOBENZOIC AND IODOXYBENZOIC ACIDS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 145 LP - 154 VL - 3 IS - 2 AU - AARON ARKIN Y1 - 1911/11/01 UR - http://jpet.aspetjournals.org/content/3/2/145.abstract N2 - 1. Sodium iodoso- and iodoxybenzoates have far greater bactericidal power than sodium iodbenzoate. Toward B. typhosus sodium iodosobenzoate is one hundred times and sodium iodoxybenzoate is two hundred times as bactericidal as sodium iodbenzoate. This difference must be attributed to the oxidizing action of the former substances. 2. Toward B. typhosus and B. coli sodium iodoxybenzoate is twice as strong as sodium iodosobenzoate. 3. Toward B. pyocyaneus sodium iodoxybenzoate is about 1.5 times as bactericidal as sodium iodosobenzoate. 4. Toward Staphylococcus aureus sodium iodosobenzoate is about five times as bactericidal as sodium iodoxybenzoate. 5. The presence of either 83⅓ per cent blood serum or 4⅙ per cent gelatin does not diminish the bactericidal action of sodium iodoxybenzoate. 6. The comparison of the bactericidal action of these three subtances furnishes an interesting example of the influences of chemical constitution on bactericidal action. In conclusion I desire to thank Dr. A. S. Loevenhart for suggesting this work to me and for his assistance in carrying it out. ER -