PT - JOURNAL ARTICLE AU - W. E. GROVE AU - A. S. LOEVENHART TI - THE ACTION OF HYDROCYANIC ACID ON THE RESPIRATION AND THE ANTAGONISTIC ACTION OF SODIUM IODOSOBENZOATE DP - 1911 Nov 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 131--144 VI - 3 IP - 2 4099 - http://jpet.aspetjournals.org/content/3/2/131.short 4100 - http://jpet.aspetjournals.org/content/3/2/131.full SO - J Pharmacol Exp Ther1911 Nov 01; 3 AB - 1. Hydrocyanic acid administered intravenously to rabbits in doses of 0.5 to 1 mg. per kilo or sodium cyanide in doses of 1 to 2 mg. per kilo causes temporary stoppage of the respiration in passive expiration for periods varying from a few seconds to nearly four minutes. The injection must be made rapidly. 2. The respiratory center is more sensitive to hydrocyanic acid than the vaso-motor center and the latter is apparently more sensitive than the cardio-inhibitory center. 3. The action of hydrocyanic acid on the respiration and circulation resembles so closely that of certain other drugs which cause temporary stoppage of the respiration (phenylmethylisoxazolchlormethylate; Tappeiner), tetramethyl-ammonium chloride (Jodlbauer), quaternary paverin bases (Pohl) and protocatechyl-tropeine (Marshall) that it suggests the possibility that these drugs owe their activity as does hydrocyanic acid to their power to inhibit physiological oxidation in the cells upon which they act. 4. We have established that a definite antagonism exists between hydrocyanic acid and sodium iodosobenzoate in regard to the respiratory center. This antagonism would further indicate that iodosobenzoate is capable of accelerating normal physiological oxidation.