TY - JOUR T1 - Pharmacogenetic Considerations in Diseases of Cardiac Ion Channels JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 831 LP - 838 DO - 10.1124/jpet.103.054569 VL - 307 IS - 3 AU - Arun Anantharam AU - Steven M. Markowitz AU - Geoffrey W. Abbott Y1 - 2003/12/01 UR - http://jpet.aspetjournals.org/content/307/3/831.abstract N2 - Phenotypic variation within a species arises from differences in genetic makeup between individuals. This inherent diversity empowers the species as a whole to explore and expand into new environmental niches and also to survive new stressors within an ever-changing environment. Paradoxically, one class of stressors currently challenging the human population is therapeutic drugs: medications designed to combat disease are often associated with a host of nonspecific side effects. Following earlier studies of the involvement of some cardiac ion currents in unwanted drug interactions, recent reports have identified not only the ion channel subunits involved but also a range of mutations and single nucleotide polymorphisms in ion channel genes that predispose to both drug-induced and familial cardiac arrhythmia. The tendency for individuals harboring specific, often common, gene variants to succumb to life-threatening cardiac arrhythmia, and the contribution of other factors such as drug interaction to disease etiology in these cases, are discussed here together with potential pharmacogenetic strategies for arrhythmia circumvention and therapy. The American Society for Pharmacology and Experimental Therapeutics ER -