RT Journal Article
SR Electronic
T1 Sources and Significance of Plasma Levels of Catechols and Their Metabolites in Humans
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 800
OP 811
DO 10.1124/jpet.103.049270
VO 305
IS 3
A1 David S. Goldstein
A1 Graeme Eisenhofer
A1 Irwin J. Kopin
YR 2003
UL http://jpet.aspetjournals.org/content/305/3/800.abstract
AB Human plasma contains several catechols, including the catecholamines norepinephrine, epinephrine, and dopamine, their precursor, l-3,4-dihydroxyphenylalanine (l-DOPA), and their deaminated metabolites, dihydroxyphenylglycol, the main neuronal metabolite of norepinephrine, and dihydroxyphenylacetic acid, a deaminated metabolite of dopamine. Products of metabolism of catechols include 3-methoxytyrosine (from l-DOPA), homovanillic acid and dopamine sulfate (from dopamine), normetanephrine, vanillylmandelic acid, and methoxyhydroxyphenylglycol (from norepinephrine), and metanephrine (from epinephrine). Plasma levels of catechols and their metabolites have related but distinct sources and therefore reflect different functions of catecholamine systems. This article provides an update about plasma levels of catechols and their metabolites and the relevance of those levels to some issues in human health and disease. The American Society for Pharmacology and Experimental Therapeutics