PT  - JOURNAL ARTICLE
AU  - J. V. SUPNIEWSKI
TI  - THE TOXIC ACTION OF ACETALDEHYDE ON THE ORGANS OF VERTEBRATA
DP  - 1927 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 429--437
VI  - 30
IP  - 6
4099  - http://jpet.aspetjournals.org/content/30/6/429.short
4100  - http://jpet.aspetjournals.org/content/30/6/429.full
SO  - J Pharmacol Exp Ther1927 Apr 01; 30
AB  - 1. Acetaldehyde kills Paramecium caudatum in a solution 1:800. 2. Acetaldehyde causes a depression of the central nervous system of vertebrates. Small doses of acetaldehyde stimulate the respiratory center and lower blood pressure, larger ones paralyze the respiration. 3. Larger doses of acetaldehyde stop the secretion of the urine. 4. Acetaldehyde relaxes the smooth muscles of the intestines, vessels, bladder and uterus. 5. Large doses of acetaldehyde depress the irritability and contractibility of the skeletal muscles of the frog. 6. Acetaldehyde in a concentration below 1:1000 is non toxic for the isolated organs of the warm blooded animals.