PT  - JOURNAL ARTICLE
AU  - Tadashi Tsubouchi
AU  - Takaharu Saito
AU  - Fujie Mizutani
AU  - Toshie Yamauchi
AU  - Yuji Iwanaga
TI  - Stimulatory Action of Itopride Hydrochloride on Colonic Motor Activity in Vitro and in Vivo
AID  - 10.1124/jpet.102.048603
DP  - 2003 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 787--793
VI  - 306
IP  - 2
4099  - http://jpet.aspetjournals.org/content/306/2/787.short
4100  - http://jpet.aspetjournals.org/content/306/2/787.full
SO  - J Pharmacol Exp Ther2003 Aug 01; 306
AB  - We investigated the effects of itopride hydrochloride (itopride, N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide hydrochloride), a gastroprokinetic agent, on the colonic motor activity in vitro and in vivo, in comparison with benzamides, cisapride hydrate (cisapride), and mosapride citrate (mosapride). Itopride stimulated both peristaltic and segmental motility induced by applying intraluminal pressure to the isolated guinea pig colon. Although cisapride and mosapride enhanced the segmental motility, they markedly reduced the peristaltic motility. In conscious dogs with implanted strain gauge force transducers, itopride stimulated contractile activity in the gastrointestinal tract from the stomach to the colon. Cisapride stimulated contractile activity in the gastric antrum, ileum, and ascending colon. Mosapride stimulated contractile activity only in the gastric antrum and ileum. In guinea pigs and rats, itopride accelerated colonic luminal transit. On the other hand, cisapride and mosapride failed to enhance colonic transit. These results demonstrate that itopride has a stimulatory action on colonic peristalsis, propelling colonic luminal contents, different from that of cisapride and mosapride. Therefore, itopride may be a useful drug for the treatment of functional bowel disorders such as functional constipation. The American Society for Pharmacology and Experimental Therapeutics