TY - JOUR T1 - IV. STUDIES ON QUININ JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 347 LP - 350 VL - 30 IS - 4 AU - ROBERT A. HATCHER AU - HARRY GOLD Y1 - 1927/02/01 UR - http://jpet.aspetjournals.org/content/30/4/347.abstract N2 - Three specimens of blood were drawn from three patients after intervals of from six to twenty minutes following the intravenous injection of doses of 10 grains (650 mgm.) of quinin dihydrochlorid in each case and examined for quinin. None of the three contained more than a fraction of a milligram, showing that much the greater part of the quinin injected had left the circulation. Twelve specimens, averaging about 0.25 per cent of the total blood, drawn from twelve patients after intervals of about 30 minutes in 7 cases, and up to two days in the others following the administration of quinin in varying doses and by different methods, were examined. No quinin could be detected in any single specimen, but a trace was recovered from the combined extracts of all the specimens. It is probable that less than 1 per cent of the quinin administered to any one of the twelve patients remained in the circulation at the time the specimen was taken. The twelve patients took a total of 14,500 mgm. (940 grains) of quinin salts. ER -