PT  - JOURNAL ARTICLE
AU  - SOMA WEISS
AU  - ROBERT A. HATCHER
TI  - II. STUDIES ON QUININ
DP  - 1927 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 327--333
VI  - 30
IP  - 4
4099  - http://jpet.aspetjournals.org/content/30/4/327.short
4100  - http://jpet.aspetjournals.org/content/30/4/327.full
SO  - J Pharmacol Exp Ther1927 Feb 01; 30
AB  - 1. The toxicity of quinin depends in part on the rate at which it enters the circulation. The fatal dose of the hydrochlorid for the cat is about 140 mgm. per kilogram of weight when it is injected intravenously at the rate of 2 mgm. per kilogram per minute, and about 100 mgm. is fatal when it is injected at the rate of 5 mgm. per minute. 2. The cat recovers within about three hours from the toxic effects of 70 per cent of the fatal dose injected intravenously at the rate of 5 mgm. per kilogram per minute, and the animal then requires as much as the normal animal, or one which had not previously had quinin, to cause death. 3. The exclusion of the kidneys from the circulation (by tying the renal arteries and veins) has no important influence on the rate of recovery after such toxic doses. 4. The perfused liver is capable of destroying quinin rapidly, and the greater part of an intravenous dose of quinin is almost certainly destroyed in the liver.