PT  - JOURNAL ARTICLE
AU  - Ursula Sonnewald
AU  - Hong Qu
AU  - Michael Aschner
TI  - Pharmacology and Toxicology of Astrocyte-Neuron Glutamate Transport and Cycling
AID  - 10.1124/jpet.301.1.1
DP  - 2002 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 1--6
VI  - 301
IP  - 1
4099  - http://jpet.aspetjournals.org/content/301/1/1.short
4100  - http://jpet.aspetjournals.org/content/301/1/1.full
SO  - J Pharmacol Exp Ther2002 Apr 01; 301
AB  - The interaction between astrocytes and neurons is examined from the standpoint of glutamate neurotoxicity. The review details 1) the distribution of glutamate transporters on astrocytes and neurons, provoking a reformulation of the interdependence between these two cell types in removing extracellular glutamate and preventing excitotoxic injury; 2) the potential involvement of aberrant glutamate transporter function in the etiology of neuropathological conditions; 3) the role of astrocyte-neuron interaction in widely divergent aspects of brain energetics; 4) the role of astrocytes in the process of glutamate recycling within the context of anesthetic treatment with pentobarbital and thiopental. The American Society for Pharmacology and Experimental Therapeutics