PT - JOURNAL ARTICLE AU - Tinna M. Laughlin AU - Kevin V. Tram AU - George L. Wilcox AU - Angela K. Birnbaum TI - Comparison of Antiepileptic Drugs Tiagabine, Lamotrigine, and Gabapentin in Mouse Models of Acute, Prolonged, and Chronic Nociception AID - 10.1124/jpet.302.3.1168 DP - 2002 Sep 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 1168--1175 VI - 302 IP - 3 4099 - http://jpet.aspetjournals.org/content/302/3/1168.short 4100 - http://jpet.aspetjournals.org/content/302/3/1168.full SO - J Pharmacol Exp Ther2002 Sep 01; 302 AB - Some antiepileptic drugs have been shown to be clinically effective in the treatment of neuropathic pain. This study determined whether the new antiepileptic drug tiagabine, a GABA uptake inhibitor, is efficacious in mice in a broad range of nociceptive tests (hot-plate, formalin, and dynorphin-induced chronic allodynia) and compared tiagabine's potency with two other antiepileptic drugs, gabapentin and lamotrigine. Intraperitoneally administered tiagabine, but not lamotrigine, gabapentin, or i.t. tiagabine, produced dose-dependent antinoception in the hot-plate test. A 5-min pretreatment with tiagabine (2–29 nmol i.t.) dose-dependently inhibited both the acute and late phase formalin behaviors; pretreatment with lamotrigine (4–265 nmol i.t.) inhibited only the late phase. In the formalin assay the GABAA antagonist bicuculline reversed the acute phase antinociception, whereas the GABAB antagonist saclofen reversed both the acute and late phase tiagabine-induced antinociception. Tiagabine administered i.p. but not i.t. dose-dependently reduced dynorphin-induced chronic allodynia for 120 min. Gabapentin and lamotrigine produced antinociception administered either i.t. or i.p. in a dose-dependent manner. Thus, we have shown that gabapentin and lamotrigine produced antinociception in two mouse models of pain, whereas tiagabine produced antinociception in all three mouse models of pain. The American Society for Pharmacology and Experimental Therapeutics