TY - JOUR T1 - Sex- and Estrous Cycle-Related Differences in the Effects of Acute Antipsychotic Drug Administration on Neurotensin-Containing Neurons in the Rat Brain JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 205 LP - 211 VL - 295 IS - 1 AU - Becky Kinkead AU - Steven M. Lorch AU - Michael J. Owens AU - Charles B. Nemeroff Y1 - 2000/10/01 UR - http://jpet.aspetjournals.org/content/295/1/205.abstract N2 - The effects of a single injection of haloperidol (2.0 mg/kg), a typical antipsychotic drug, on neurotensin (NT) concentrations and NT/neuromedin N (NT/NN) mRNA expression in adult female and male rats were examined. There were significant estrous cycle stage-related differences in both NT concentrations and NT/NN mRNA expression in female control rats. Although acute administration of haloperidol increased NT concentrations and NT/NN mRNA expression in the caudate/putamen and nucleus accumbens of both male and female rats, haloperidol did not increase NT/NN mRNA expression during diestrus 2 or NT concentrations during proestrus in the nucleus accumbens of female rats. These results indicate the presence of both sex- and estrous cycle-related differences in the regulation of NT-containing neurons and in the effects of antipsychotic drug administration on the NT system of the rat brain. The American Society for Pharmacology and Experimental Therapeutics ER -