RT Journal Article
SR Electronic
T1 Effects of Pramipexole on Contraversive Rotation and Functional Motor Impairments in 1-Methyl-4-phenyl1,2,3,6-tetrahydropyridine-Induced Chronic Hemiparkinsonian Monkeys
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 983
OP 987
VO 287
IS 3
A1 Edward F. Domino
A1 Lisong Ni
A1 Huilei Zhang
A1 Yasuko Kohno
A1 Masashi Sasa
YR 1998
UL http://jpet.aspetjournals.org/content/287/3/983.abstract
AB Rotational and functional motor behavioral changes were studied in five MPTP lesioned chronic hemiparkinsonian Macaca nemestrinamonkeys after i.m. pramipexole, a predominant D2 subfamily agonist. Pramipexole induced contraversive rotations in a dose-dependent manner with an optimal dose of 56 μg/kg for ∼2 to 4 hr after injection. Three different rating scales were used to determine drug-induced functional improvement. They included a monkey parkinsonism rating scale, volitional responses to fruit presentations, and number of hand movements that appeared volitional. A dose of 56 μg/kg of pramipexole produced functional improvements on hand disability, and on a parkinsonian rating scale for monkeys in a dose-dependent manner from 32 to 100 μg/kg. These doses produced an increase in significant hand movements in the affected (contralateral) as well as in the normal (ipsilateral) hand to the side of the brain lesion compared with 5% dextrose in water vehicle control. With a dose of 100 μg/kg, the therapeutic effects of pramipexole on hand movements were less than with 56 μg/kg, due to side effects such as scratching. The American Society for Pharmacology and Experimental Therapeutics