@article {HUNT367, author = {REID HUNT}, title = {SOME EFFECTS OF QUATERNARY AMMONIUM COMPOUNDS ON THE AUTONOMIC NERVOUS SYSTEM}, volume = {28}, number = {3}, pages = {367--388}, year = {1926}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {1. The toxicity of the tetra-alkyl ammonium compounds decreased from the methyl to the ethyl and then increased; the n-butyl compound was three times as toxic as the methyl compound. The toxicity of the mixed alkyl compounds was determined by the individual alkyl groups present but was not strictly parallel to their relative numbers. 2. Typical "muscarine" effects were produced only by tri- and tetra-methyl compounds. 3. The most marked stimulating "nicotine" action upon the ganglion cells of the autonomic nervous system resulted from the methyl compounds. 4. A paralyzing "nicotine" action on the ganglion cells of the autonomic nervous system resulted from a great variety of the alkyl onium compounds; it was not limited to the methyl compounds as was the muscarine and marked stimulating "nicotine" action. 5. None of these compounds seemed to have an atropine action in mammals. Note: Trimethyl tin hydroxide (which was prepared by Professor C. A. Kraus who kindly gave me a sample) had, in doses of 20 and (1 case) even 100 mgm., no "muscarine" action; large doses (20 mgm.) sometimes caused a slight rise of blood pressure and an acceleration of the heart but this did not seem to be an action of the nicotine type. It had no atropine action. This compound was very toxic to mice when injected subcutaneously, the fatal dose being approximately 0.0018 mgm. per gram; the fatal period was long, death frequently not occurring for twenty-five hours or more even after the administration of a dose several times greater than the average fatal dose. The compound was approximately ten times as poisonous as the most toxic of the ammonium compounds studied in the above series; the fatal period of the latter was in most cases very short.}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/28/3/367}, eprint = {https://jpet.aspetjournals.org/content/28/3/367.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }