RT Journal Article
SR Electronic
T1 PLEXUS-FREE PREPARATIONS OF THE SMALL INTESTINE A STUDY OF THEIR RHYTHMICITY AND OF THEIR RESPONSE TO DRUGS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 395
OP 410
VO 27
IS 5
A1 HERBERT S. GASSER
YR 1926
UL http://jpet.aspetjournals.org/content/27/5/395.abstract
AB Smooth muscle strips were made from the inner circular coat of the intestine of the cat. A histological investigation showed that some at least were free from nerve cells. Such plexus-free preparations were found to be rhythmic (confirming Gunn and Underhill) and to respond to pilocarpine, physostigmine, atropine and adrenaline but not to nicotine (confirming Magnus). In addition they were found responsive to natural muscarine and acetyl-choline. The experiments are presented as additional evidence that Auerbach's plexus is not necessary for pendular movements of the small intestine and that, with the exception of nicotine the alkaloids and bases above mentioned produce their effects by direct action on the muscle fibers and not through the plexus. It is a great pleasure to have this opportunity to thank the members of the Medical Research Council of Great Britain for their kindness in allowing these experiments to be carried out in the National Institute for Medical Research, and Dr. H. H. Dale, in particular, in whose laboratory the experiments were performed and whose advice was very generously given throughout their progress.